Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA037077-03S1
Application #
3174748
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1984-04-01
Project End
1987-04-30
Budget Start
1986-04-01
Budget End
1987-04-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Toronto
Department
Type
DUNS #
259999779
City
Toronto
State
ON
Country
Canada
Zip Code
M5 1S8
Laconi, S; Curreli, F; Diana, S et al. (1999) Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study. J Hepatol 31:1069-74
Manjeshwar, S; Rao, P M; Rajalakshmi, S et al. (1999) The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo. Mol Carcinog 24:188-96
Tomasi, C; Laconi, E; Laconi, S et al. (1999) Effect of fasting/refeeding on the incidence of chemically induced hepatocellular carcinoma in the rat. Carcinogenesis 20:1979-83
Yusuf, A; Rao, P M; Rajalakshmi, S et al. (1999) Development of resistance during the early stages of experimental liver carcinogenesis. Carcinogenesis 20:1641-4
Yusuf, A; Laconi, E; Rao, P M et al. (1999) The effect of 1/3 partial hepatectomy on the growth of glutathione S-transferase positive foci. Carcinogenesis 20:1143-5
Vasudevan, S; Laconi, E; Rao, P M et al. (1998) Cycloheximide sensitivity of orotic acid biosynthesis induced by ammonia and glycine administration. Eur J Biochem 251:597-604
Laconi, E; Yusuf, A; Jahangir, A R et al. (1997) Transient inhibition by orotic acid does not abolish the in vivo response of rat hepatocytes to a direct mitogen, lead nitrate. J Hepatol 26:203-8
Pascale, R M; Simile, M M; De Miglio, M R et al. (1995) Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid. Carcinogenesis 16:427-30
Laconi, E; Sarma, D S; Pani, P (1995) Transplantation of normal hepatocytes modulates the development of chronic liver lesions induced by a pyrrolizidine alkaloid, lasiocarpine. Carcinogenesis 16:139-42
Laconi, E; Tessitore, L; Milia, G et al. (1995) The enhancing effect of fasting/refeeding on the growth of nodules selectable by the resistant hepatocyte model in rat liver. Carcinogenesis 16:1865-9

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