We are using the tools of oncogenetics and viral genetics to study the molecular events that might be responsible for the well- established relationship between chronic infection with hepatitis B viruses and the appearance of primary hepatocellular carcinoma. In this application to continue an established program, we emphasize two general approaches: (1) The behavior of wild-type and recombinant rodent hepatitis B viruses is being examined in two natural hosts for such viruses, the Eastern woodchuck and Beechey ground squirrel, to identify viral and host determinants of host range and pathogenicity. (2) A collection of PHCs from patients in Hong Kong is being analyzed for rearrangements and aberrant expression of known cellular proto-oncogenes and for insertional activation of chromosomal domains that might harbor previously unknown proto-oncogenes by hepatitis virus DNA.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037281-06
Application #
3175121
Study Section
Experimental Virology Study Section (EVR)
Project Start
1984-03-01
Project End
1990-02-28
Budget Start
1989-03-01
Budget End
1990-02-28
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143