For the last several years our laboratory has been concerned with the biochemical genetics of cell surface antigens and with the immunogenetics of bone marrow engraftment. In this proposal, I outline planned research: 1) to analyze the genetics of bone marrow transplantation in mice. 2) to carry out studies on the genetics of beta 2 microglobulin in man by utilizing a restriction- fragment polymorphism of the B2M gene 3) to produce additional Qa/TL monoclonal antibodies 4) to use biochemical methods to study the array of B2M-associated molecules and 5) to analyze the expression of transfected Qa/T1a region genes.
| Michaelson, J (1993) Cellular selection in the genesis of multicellular organization. Lab Invest 69:136-51 |
| Salant, E; Michaelson, J (1990) TL.8, a new antigenic determinant of the TL system. Immunogenetics 31:410-1 |
| Whitehead, A S; Rits, M; Michaelson, J (1988) Molecular genetics of mouse serum amyloid P component (SAP): cloning and gene mapping. Immunogenetics 28:388-90 |
| Perkins, D L; Michaelson, J; Marshak-Rothstein, A (1987) The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice. J Immunol 138:466-9 |
| Michaelson, J; Boyse, E A; Ciccia, L et al. (1986) Biochemical genetics of TL antigens. Immunogenetics 24:103-14 |
