Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA037387-02S1
Application #
3175251
Study Section
(SRC)
Project Start
1985-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Brooks, Sam C; Skafar, Debra F (2004) From ligand structure to biological activity: modified estratrienes and their estrogenic and antiestrogenic effects in MCF-7 cells. Steroids 69:401-18
Wiese, T E; Polin, L A; Palomino, E et al. (1997) Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study. J Med Chem 40:3659-69
Wiese, T E; Dukes, D; Brooks, S C (1995) A molecular modeling analysis of diethylstilbestrol conformations and their similarity to estradiol-17 beta. Steroids 60:802-8
Davis, M D; Butler, W B; Brooks, S C (1995) Induction of tissue plasminogen activator mRNA and activity by structurally altered estrogens. J Steroid Biochem Mol Biol 52:421-30
Palomino, E; Heeg, M J; Horwitz, J P et al. (1994) Skeletal conformations and receptor binding of some 9,11-modified estradiols. J Steroid Biochem Mol Biol 50:75-84
Wiese, T E; Brooks, S C (1994) Molecular modeling of steroidal estrogens: novel conformations and their role in biological activity. J Steroid Biochem Mol Biol 50:61-73
VanderKuur, J A; Brooks, S C (1994) Effect of A-ring isomers of estradiol-17 beta on gene products in MCF-7 cells. Steroids 59:548-54
VanderKuur, J A; Wiese, T; Brooks, S C (1993) Influence of estrogen structure on nuclear binding and progesterone receptor induction by the receptor complex. Biochemistry 32:7002-8
Wiese, T E; Kral, L G; Dennis, K E et al. (1992) Optimization of estrogen growth response in MCF-7 cells. In Vitro Cell Dev Biol 28A:595-602
Palomino, E; Heeg, M J; Horwitz, J P et al. (1990) Binding, X-ray and NMR studies of the three A-ring isomers of natural estradiol. J Steroid Biochem 35:219-29

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