Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037392-15
Application #
2089325
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1983-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Mucka, Patrick; Levonyak, Nicholas; Geretti, Elena et al. (2016) Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency. Am J Pathol 186:2803-2812
Akino, Tomoshige; Han, Xuezhe; Nakayama, Hironao et al. (2014) Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma. Cancer Res 74:3716-26
Panigrahy, Dipak; Adini, Irit; Mamluk, Roni et al. (2014) Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration. Pathology 46:416-23
Coma, Silvia; Allard-Ratick, Marc; Akino, Tomoshige et al. (2013) GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis 16:939-52
Snuderl, Matija; Batista, Ana; Kirkpatrick, Nathaniel D et al. (2013) Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152:1065-76
Buehler, Anima; Sitaras, Nicholas; Favret, Sandra et al. (2013) Semaphorin 3F forms an anti-angiogenic barrier in outer retina. FEBS Lett 587:1650-5
Shimizu, Akio; Nakayama, Hironao; Wang, Priscilla et al. (2013) Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem 288:2210-22
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Wong, Hon-Kit; Shimizu, Akio; Kirkpatrick, Nathaniel D et al. (2012) Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia 14:84-94
Coma, Silvia; Shimizu, Akio; Klagsbrun, Michael (2011) Hypoxia induces tumor and endothelial cell migration in a semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor neuropilin 2. Cell Adh Migr 5:266-75

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