Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA037853-03S2
Application #
3175713
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1984-07-01
Project End
1988-03-31
Budget Start
1987-12-01
Budget End
1988-03-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Giuntoli 2nd, R L; Stoykova, L I; Gillies, D R et al. (1994) Expression of GDP-L-Fuc: Gal(beta 1-4)GlcNAc-R (Fuc to GlcNAc) alpha-1,3-fucosyltransferase and its relationship to glycoprotein structure in a human erythroleukemia cell line, HEL. Eur J Biochem 225:159-66
Negishi, M; van Kuik, J A; Vliegenthart, J F et al. (1992) Oligosaccharide composition of the neurotoxin-responsive sodium channel of mouse neuroblastoma and requirement of sialic acid for biological activity. Carbohydr Res 236:209-25
Foster, C S; Gillies, D R; Glick, M C (1991) Purification and characterization of GDP-L-Fuc-N-acetyl-beta-D-glucosaminide alpha 1----3fucosyltransferase from human neuroblastoma cells. Unusual substrate specificities of the tumor enzyme. J Biol Chem 266:3526-31
Santer, U V; DeSantis, R; Hard, K J et al. (1989) N-linked oligosaccharide changes with oncogenic transformation require sialylation of multiantennae. Eur J Biochem 181:249-60
Livingston, B D; Jacobs, J L; Glick, M C et al. (1988) Extended polysialic acid chains (n greater than 55) in glycoproteins from human neuroblastoma cells. J Biol Chem 263:9443-8
Boyd, J P; Glick, M C (1988) Removal of polypeptides from human neuroblastoma antigen does not alter recognition by monoclonal antibody PI 153/3. Prog Clin Biol Res 271:353-8
DeSantis, R; Santer, U V; Glick, M C (1987) NIH 3T3 cells transfected with human tumor DNA lose the transformed phenotype when treated with swainsonine. Biochem Biophys Res Commun 142:348-53
Woodbury, R A; Santer, U V; Elkins, W L et al. (1986) Similarities in glycosylation of human neuroblastoma tumors and cell lines. Cancer Res 46:3692-7
Emanuel, B S; Balaban, G; Boyd, J P et al. (1985) N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas. Proc Natl Acad Sci U S A 82:3736-40
Glick, M C; De Santis, R; Santer, U V (1985) Glycosylation changes in membrane glycoproteins after transfection of NIH 3T3 with human tumor DNA. Prog Clin Biol Res 175:229-37