The long-term objective of this research is to study the role of cyclooxygenase products of arachidonic acid metabolism in tumor growth and metastasis.
The specific aims are: (1) to determine the effects of cyclooxygenase inhibitors on the growth and metastasis of murine mammary adenocarcinomas and (2) to define the interactions between tumor-associated cyclooxygenase products and antitumor immune effector functions. We have now shown that cyclooxygenase inhibitors reduce the spontaneous metastasis of these tumors and that this effect may be mediated by increasing the susceptibility of these tumor cells to killing by both macrophage and natural cytotoxic effector cells. These studies will focus on determining the effects of cyclooxygenase inhibitors on the nature of host infiltrates within tumors and evaluating the effect these inhibitors have on immune effector cells. Defining the role of these naturally-occurring products in tumor growth and understanding how these products affect immune function will provide a rational basis for designing immunotherapeutic agents. (HF)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA037943-02
Application #
3175898
Study Section
Pathology B Study Section (PTHB)
Project Start
1984-07-01
Project End
1987-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Barbara Ann Karmanos Cancer Institute
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48201
Zhang, S Z; Fulton, A M (1994) Modulation of integrin-laminin receptor function on mammary tumor cells by prostaglandin E2 receptor antagonism. Cancer Lett 85:233-8
Fulton, A M; Chong, Y C (1992) Prostaglandin E2 receptor activity and susceptibility to natural killer cells. J Leukoc Biol 51:176-80
Fulton, A M; Zhang, S Z; Chong, Y C (1991) Role of the prostaglandin E2 receptor in mammary tumor metastasis. Cancer Res 51:2047-50
Zhang, S Z; Fulton, A M (1991) Prostaglandin E2 receptor modulation affects tumor cell adhesion to laminin. J Cell Physiol 149:208-13
Wei, W Z; Fulton, A; Winkelhake, J et al. (1989) Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion. Cancer Res 49:2709-15
Fulton, A M; Laterra, J J; Hanchin, C M (1989) Prostaglandin E2 receptor heterogeneity and dysfunction in mammary tumor cells. J Cell Physiol 139:93-9
Chong, Y C; Heppner, G H; Paul, L A et al. (1989) Macrophage-mediated induction of DNA strand breaks in target tumor cells. Cancer Res 49:6652-7
Fulton, A M (1988) Inhibition of experimental metastasis with indomethacin: role of macrophages and natural killer cells. Prostaglandins 35:413-25
Fulton, A M (1988) The role of eicosanoids in tumor metastasis. Prostaglandins Leukot Essent Fatty Acids 34:229-37
Fulton, A M (1987) Interactions of natural effector cells and prostaglandins in the control of metastasis. J Natl Cancer Inst 78:735-41