The MCS was established in 1984 to evaluate the natural history of HTLV-I in two endemic communities in southwestern Japan; the prevalence of infection is currently 27% among the nearly 2000 participants. It was recently discovered that one of these communities also has a prevalence of HCV of about 26%. The plan is to extend and expand the preliminary studies on the natural history of HCV, to consolidate the work on the natural history of HTLV-I, and to evaluate the effect of co-infection of these two newly identified viruses. Specifically, the application proposes: to describe the pattern and distribution of seromarkers of HCV infection; to examine the stability of markers within the host, over time; to develop an operational definition of HCV infection; to evaluate the relevance of various HCV seromarkers with respect to liver function over time and in relation to reported liver disease; to investigate the effect of HCV infection on overall and cause-specific morbidity and mortality; to evaluate whether there is evidence that HCV infection is immunosuppressive; to describe the viral marker profiles in subjects co-infected with both HCV and HTLV-I; to identify the HTLV-I viral markers and demographic risk factors predictive of proviral clonality among carriers; to evaluate the interaction of HTLV-I infection and Helicobacter pylori in the risk of peptic ulcer and of gastric cancer; to describe the evolution of HTLV-I parameters in seroconvertors and to identify additional viral correlates of transmission from infected spouses; to evaluate the levels of various soluble T-cell surface markers as an index of viral status.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA038450-12
Application #
2007470
Study Section
Special Emphasis Panel (ZRG4-EDC-2 (01))
Project Start
1988-12-15
Project End
2000-11-30
Budget Start
1997-03-20
Budget End
1997-11-30
Support Year
12
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Birmann, Brenda M; Breen, Elizabeth C; Stuver, Sherri et al. (2009) Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica. Int J Cancer 124:614-21
Tanaka, Gen-ichi; Okayama, Akihiko; Watanabe, Toshiki et al. (2005) The clonal expansion of human T lymphotropic virus type 1-infected T cells: a comparison between seroconverters and long-term carriers. J Infect Dis 191:1140-7
Hisada, Michie; Stuver, Sherri O; Okayama, Akihiko et al. (2004) Persistent paradox of natural history of human T lymphotropic virus type I: parallel analyses of Japanese and Jamaican carriers. J Infect Dis 190:1605-9
Okayama, Akihiko; Stuver, Sherri; Matsuoka, Masao et al. (2004) Role of HTLV-1 proviral DNA load and clonality in the development of adult T-cell leukemia/lymphoma in asymptomatic carriers. Int J Cancer 110:621-5
Birmann, Brenda M; Mueller, Nancy; Okayama, Akihiko et al. (2004) Serologic assessment of type 1 and type 2 immunity in healthy Japanese adults. Cancer Epidemiol Biomarkers Prev 13:1385-91
Raker, Christina A; Tabor, Edward; Okayama, Akihiko et al. (2004) HCV core antigen as an alternative to NAT to detect HCV viremia. Transfusion 44:307-8
Iga, Mutsunori; Okayama, Akihiko; Stuver, Sherri et al. (2002) Genetic evidence of transmission of human T cell lymphotropic virus type 1 between spouses. J Infect Dis 185:691-5
Okayama, A; Stuver, S O; Tabor, E et al. (2002) Incident hepatitis C virus infection in a community-based population in Japan. J Viral Hepat 9:43-51
Ishizaki, Junzo; Okayama, Akihiko; Kuroki, Masayuki et al. (2002) Detection of human T-lymphotropic virus type I (HTLV-I) infection during coculture of HTLV-I infected and uninfected cells using inverse long PCR. Intervirology 45:164-71
Arduino, J M; Stuver, S O; Spiegelman, D et al. (2001) Assessment of markers of hepatitis C virus infection in a Japanese adult population. J Infect Dis 184:1229-35

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