Abstract

The objective of the proposed program is to utilize the recently developed method of stable isotope enrichment and the concept of simultaneous double labeling to study some fundamental features of selenium nutrition and metabolism directly in healthy human adults in order to acquire the necessary, and at present missing, data base for later application to human nutrition and metabolism of selenium under unhealthful physiologic and dietary conditions. The parameters of nutrition and metabolism to be measured directly with this novel tracer methodology are gastrointestina absorption, urinary excretion (quantitative and dynamics), longterm body retention, nature and quantitative significance of urinary metabolites, and the first pass effect of the liver. The dietary and host factors to be investigated are: dietary forms of selenium and body selenium status.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA038943-02
Application #
3177460
Study Section
(SSS)
Project Start
1984-03-01
Project End
1987-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Janghorbani, M; Mooers, C S; Smith, M A et al. (1991) Correlation between the size of the selenite-exchangeable metabolic pool and total body or liver selenium in rats. J Nutr 121:345-54
Janghorbani, M; Lynch, N E; Mooers, C S et al. (1990) Comparison of the magnitude of the selenite-exchangeable metabolic pool and whole body endogenous selenium in adult rats. J Nutr 120:190-9
Janghorbani, M; Rockway, S; Mooers, C S et al. (1990) Effect of chronic selenite supplementation on selenium excretion and organ accumulation in rats. J Nutr 120:274-9
Janghorbani, M; Martin, R F; Kasper, L J et al. (1990) The selenite-exchangeable metabolic pool in humans: a new concept for the assessment of selenium status. Am J Clin Nutr 51:670-7
Ting, B T; Mooers, C S; Janghorbani, M (1989) Isotopic determination of selenium in biological materials with inductively coupled plasma mass spectrometry. Analyst 114:667-74
Janghorbani, M; Ting, B T (1989) Comparison of pneumatic nebulization and hydride generation inductively coupled plasma mass spectrometry for isotopic analysis of selenium. Anal Chem 61:701-8
Martin, R F; Janghorbani, M; Young, V R (1989) Experimental selenium restriction in healthy adult humans: changes in selenium metabolism studied with stable-isotope methodology. Am J Clin Nutr 49:854-61
Martin, R F; Young, V R; Blumberg, J et al. (1989) Ascorbic acid-selenite interactions in humans studied with an oral dose of 74SeO3(2-). Am J Clin Nutr 49:862-9
Martin, R F; Janghorbani, M; Young, V R (1988) Kinetics of a single administration of 74Se-selenite by oral and intravenous routes in adult humans. JPEN J Parenter Enteral Nutr 12:351-5
Sun, X F; Ting, B T; Janghorbani, M (1987) Excretion of trimethylselenonium ion in human urine. Anal Biochem 167:304-11

Showing the most recent 10 out of 12 publications