Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA038981-05
Application #
3177545
Study Section
Endocrinology Study Section (END)
Project Start
1984-12-01
Project End
1993-05-31
Budget Start
1989-03-15
Budget End
1989-05-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Kulas, D T; Zhang, W R; Goldstein, B J et al. (1995) Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR. J Biol Chem 270:2435-8
Furlanetto, R W; Harwell, S E; Frick, K K (1994) Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. Mol Endocrinol 8:510-7
Furlanetto, R W; Harwell, S E; Baggs, R B (1993) Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice. Cancer Res 53:2522-6
Korc-Grodzicki, B; Furlanetto, R W; Hilf, R (1992) Characterization of insulin-like growth factor receptors in the insulin-responsive R3230AC mammary adenocarcinoma. Oncol Res 4:109-19
Stuart, C A; Meehan, R T; Neale, L S et al. (1991) Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes. J Clin Endocrinol Metab 72:1117-22
Furlanetto, R W (1990) Metabolism of photoaffinity-labeled insulin-like growth factor-I receptors by human cells in vitro. Endocrinology 126:1334-42
Ruggeri, B A; Klurfeld, D M; Kritchevsky, D et al. (1989) Caloric restriction and 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in rats: alterations in circulating insulin, insulin-like growth factors I and II, and epidermal growth factor. Cancer Res 49:4130-4
Blazer-Yost, B L; Cox, M; Furlanetto, R (1989) Insulin and IGF I receptor-mediated Na+ transport in toad urinary bladders. Am J Physiol 257:C612-20
Ruggeri, B A; Klurfeld, D M; Kritchevsky, D et al. (1989) Growth factor binding to 7,12-dimethylbenz(a)anthracene-induced mammary tumors from rats subject to chronic caloric restriction. Cancer Res 49:4135-41
Cara, J F; Stuart, C A; Furlanetto, R W (1988) A monoclonal antibody to the type 1 insulin-like growth factor and insulin receptors stimulates deoxyribonucleic acid synthesis in human and murine fibroblasts. Endocrinology 123:1341-7

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