Aziridinyl putrescine (AZP) was found to have cytotoxic activity against PC-3 cells and this tumoricidal activity was enhanced by pretreatment with DFMO. Meso-1,4 bis-(aziridinyl) 2,3 butane (DAZOHP) is being examined for similar activity. Diaziridinyl putrescine (DAZP) is being synthesized and will be examined for similar activity. In the last year of this grant we will be examining AZP for activity in vivo. If DAZP and DAZOHP are found to have activity in vitro they will be screened for activity in vivo.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039203-02
Application #
3177973
Study Section
(SRC)
Project Start
1984-04-01
Project End
1986-08-31
Budget Start
1985-03-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
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