Abstract

Aziridinyl putrescine (AZP) was found to have cytotoxic activity against PC-3 cells and this tumoricidal activity was enhanced by pretreatment with DFMO. Meso-1,4 bis-(aziridinyl) 2,3 butane (DAZOHP) is being examined for similar activity. Diaziridinyl putrescine (DAZP) is being synthesized and will be examined for similar activity. In the last year of this grant we will be examining AZP for activity in vivo. If DAZP and DAZOHP are found to have activity in vitro they will be screened for activity in vivo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039203-02
Application #
3177973
Study Section
(SRC)
Project Start
1984-04-01
Project End
1986-08-31
Budget Start
1985-03-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Pinto, J T; Qiao, C; Xing, J et al. (1997) Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture. Am J Clin Nutr 66:398-405
Pinto, J T; Suffoletto, B P; Berzin, T M et al. (1996) Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res 2:1445-51
Vassallo, P; Matei, C; Heston, W D et al. (1994) AMI-227-enhanced MR lymphography: usefulness for differentiating reactive from tumor-bearing lymph nodes. Radiology 193:501-6
Powell, C T; Fair, W R; Heston, W D (1994) Differential expression of protein kinase C isozyme messenger RNAs in dunning R-3327 rat prostatic tumors. Cell Growth Differ 5:143-9
Manchester, K M; Heston, W D; Donner, D B (1993) Tumour necrosis factor-induced cytotoxicity is accompanied by intracellular mitogenic signals in ME-180 human cervical carcinoma cells. Biochem J 290 ( Pt 1):185-90
Heston, W D (1991) Prostatic polyamines and polyamine targeting as a new approach to therapy of prostatic cancer. Cancer Surv 11:217-38
Scher, H I; Curley, T; Geller, N et al. (1990) Trimetrexate in prostatic cancer: preliminary observations on the use of prostate-specific antigen and acid phosphatase as a marker in measurable hormone-refractory disease. J Clin Oncol 8:1830-8
Heston, W D; Charles, M (1988) Calmodulin antagonist inhibition of polyamine transport in prostatic cancer cells in vitro. Biochem Pharmacol 37:2511-4
Heston, W D; Yang, C R; Pliner, L et al. (1987) Cytotoxic activity of a polyamine analogue, monoaziridinylputrescine, against the PC-3 human prostatic carcinoma cell line. Cancer Res 47:3627-31
Heston, W D; Watanabe, K A; Pankiewicz, K W et al. (1987) Cytotoxic and non-cytotoxic N-alkyl derivatives of putrescine: effect on polyamine uptake and growth of prostatic cancer cells in vitro. Biochem Pharmacol 36:1849-52

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