This program seeks an understanding of the interaction of ultrasound with biological material in two broad perspectves: (1) Propagation of Sound in Tissue with particular emphasis on nonlinear phenomena and (2) the Biological Effects of Ultrasound. In the latter work, both thermal and nonthermal mechanisms have been demonstrated. Particularly important are studies of the mechanism of killing of Drosophila at low temporal average intensities of pulsed ultrasound, and implications of these studies for human safety.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039241-26
Application #
3178057
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1985-05-01
Project End
1990-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
26
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Child, S Z; Raeman, C H; Walters, E et al. (1992) The sensitivity of Drosophila larvae to continuous-wave ultrasound. Ultrasound Med Biol 18:725-8
Dalecki, D; Carstensen, E L; Parker, K J et al. (1991) Absorption of finite amplitude focused ultrasound. J Acoust Soc Am 89:2435-47
Child, S Z; Hoffman, D; Norton, S et al. (1991) Pulsed ultrasound and the hyperbarically exposed mouse fetus. Ultrasound Med Biol 17:367-71
Child, S Z; Hartman, C L; Schery, L A et al. (1990) Lung damage from exposure to pulsed ultrasound. Ultrasound Med Biol 16:817-25
Carstensen, E L; Child, S Z; Crane, C et al. (1990) Lysis of cells in Elodea leaves by pulsed and continuous wave ultrasound. Ultrasound Med Biol 16:167-73
Carstensen, E L; Campbell, D S; Hoffman, D et al. (1990) Killing of Drosophila larvae by the fields of an electrohydraulic lithotripter. Ultrasound Med Biol 16:687-98
Carstensen, E L; Child, S Z; Norton, S et al. (1990) Ultrasonic heating of the skull. J Acoust Soc Am 87:1310-7
Bacon, D R; Carstensen, E L (1990) Increased heating by diagnostic ultrasound due to nonlinear propagation. J Acoust Soc Am 88:26-34
Ayme-Bellegarda, E J (1990) Collapse and rebound of a gas-filled spherical bubble immersed in a diagnostic ultrasonic field. J Acoust Soc Am 88:1054-60
Carstensen, E L; Hartman, C; Child, S Z et al. (1990) Test for kidney hemorrhage following exposure to intense, pulsed ultrasound. Ultrasound Med Biol 16:681-5

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