Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA039489-02S1
Application #
3178523
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1985-06-01
Project End
1988-05-31
Budget Start
1986-06-01
Budget End
1987-05-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Vogelzang, P J; Bloom, S M; Mier, J W et al. (1992) Chest roentgenographic abnormalities in IL-2 recipients. Incidence and correlation with clinical parameters. Chest 101:746-52
Mier, J W; Vachino, G; Klempner, M S et al. (1990) Inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects. Blood 76:1933-40
Aronson, F R; Libby, P; Brandon, E P et al. (1988) IL-2 rapidly induces natural killer cell adhesion to human endothelial cells. A potential mechanism for endothelial injury. J Immunol 141:158-63
Mier, J W; Aronson, F R; Numerof, R P et al. (1988) Toxicity of immunotherapy with interleukin-2 and lymphokine-activated killer cells. Pathol Immunopathol Res 7:459-76
Mier, J W; Vachino, G; van der Meer, J W et al. (1988) Induction of circulating tumor necrosis factor (TNF alpha) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients. J Clin Immunol 8:426-36
Numerof, R P; Aronson, F R; Mier, J W (1988) IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells. J Immunol 141:4250-7
Atkins, M B; Mier, J W; Parkinson, D R et al. (1988) Hypothyroidism after treatment with interleukin-2 and lymphokine-activated killer cells. N Engl J Med 318:1557-63
Mier, J W; Dinarello, C A; Atkins, M B et al. (1987) Regulation of hepatic acute phase protein synthesis by products of interleukin 2 (IL 2)-stimulated human peripheral blood mononuclear cells. J Immunol 139:1268-72
Allegretta, M; Atkins, M B; Dempsey, R A et al. (1986) The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2). J Clin Immunol 6:481-90
Atkins, M B; Gould, J A; Allegretta, M et al. (1986) Phase I evaluation of recombinant interleukin-2 in patients with advanced malignant disease. J Clin Oncol 4:1380-91

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