Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA039545-05S1
Application #
3178646
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1985-12-01
Project End
1991-11-30
Budget Start
1990-05-01
Budget End
1990-11-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Bennett, A M; Williams, G M (1993) Alteration of rat liver endoplasmic reticulum Ca(2+)-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator. Biochem Pharmacol 45:2093-8
Bennett, A M; Williams, G M (1993) Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate. Biochem Pharmacol 46:2219-27
Budroe, J D; Umemura, T; Angeloff, K et al. (1992) Dose-response relationships of hepatic acyl-CoA oxidase and catalase activity and liver mitogenesis induced by the peroxisome proliferator ciprofibrate in C57BL/6N and BALB/c mice. Toxicol Appl Pharmacol 113:192-8
Bennett, A M; Williams, G M (1992) Reduction of rat liver endoplasmic reticulum Ca(2+)-ATPase activity and mobilization of hepatic intracellular calcium by ciprofibrate, a peroxisome proliferator. Biochem Pharmacol 43:595-605
Kahn, S M; Jiang, W; Culbertson, T A et al. (1991) Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification. Oncogene 6:1079-83
Maruyama, H; Tanaka, T; Williams, G M (1990) Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital. Toxicol Pathol 18:257-67
Butler, E G; Ichida, T; Maruyama, H et al. (1990) Toxicological studies on a benzofurane derivative. II. Demonstration of peroxisome proliferation in rat liver. Toxicol Appl Pharmacol 106:500-8
Butler, E G; England, P J; Williams, G M (1988) Genetic differences in enzymes associated with peroxisome proliferation and hydrogen peroxide metabolism in inbred mouse strains. Carcinogenesis 9:1459-63
Butler, E G; Tanaka, T; Ichida, T et al. (1988) Induction of hepatic peroxisome proliferation in mice by lactofen, a diphenyl ether herbicide. Toxicol Appl Pharmacol 93:72-80
Williams, G M; Maruyama, H; Tanaka, T (1987) Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis. Carcinogenesis 8:875-80