Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039547-11
Application #
2089863
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1985-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Yuan, W; Kiselyov, A S; Harvey, R G et al. (1995) Mutagenic specificity of syn-benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide in the dihydrofolate reductase gene of Chinese hamster ovary cells. Carcinogenesis 16:2869-73
Jin, Y; Yie, T A; Carothers, A M (1995) Non-random deletions at the dihydrofolate reductase locus of Chinese hamster ovary cells induced by alpha-particles simulating radon. Carcinogenesis 16:1981-91
Carothers, A M; Urlaub, G; Grunberger, D et al. (1993) Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol 13:5085-98
Carothers, A M; Urlaub, G; Mucha, J et al. (1993) A mutational hot spot induced by N-hydroxy-aminofluorene in dihydrofolate reductase mutants of Chinese hamster ovary cells. Carcinogenesis 14:2181-4
Carothers, A M; Zhen, W; Mucha, J et al. (1992) DNA strand-specific repair of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene. Proc Natl Acad Sci U S A 89:11925-9
Carothers, A M; Mucha, J; Grunberger, D (1991) DNA strand-specific mutations induced by (+/-)-3 alpha,4 beta-dihydroxy- 1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene in the dihydrofolate reductase gene. Proc Natl Acad Sci U S A 88:5749-53
Carothers, A M; Grunberger, D (1990) DNA base changes in benzo[a]pyrene diol epoxide-induced dihydrofolate reductase mutants of Chinese hamster ovary cells. Carcinogenesis 11:189-92
Carothers, A M; Urlaub, G; Mucha, J et al. (1990) Splicing mutations in the CHO DHFR gene preferentially induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene. Proc Natl Acad Sci U S A 87:5464-8
Carothers, A M; Steigerwalt, R W; Urlaub, G et al. (1989) DNA base changes and RNA levels in N-acetoxy-2-acetylaminofluorene-induced dihydrofolate reductase mutants of Chinese hamster ovary cells. J Mol Biol 208:417-28
Carothers, A M; Urlaub, G; Mucha, J et al. (1989) Point mutation analysis in a mammalian gene: rapid preparation of total RNA, PCR amplification of cDNA, and Taq sequencing by a novel method. Biotechniques 7:494-6, 498-9

Showing the most recent 10 out of 12 publications