The investigators will combine experimental studies with computational simulations to uncover the neural circuit mechanisms underlying taste choice behavior. A fundamental question to be addressed is how the neural activity induced by a given taste is impacted by the recent sampling of another taste and/or by the expectation that another taste is forthcoming. We will analyse data produced from ensemble recordings of neural activity and make use of optogenetic techniques that alter neural activity, to further our work on how specific features of such activity impact behavior during a decision making task. These data will provide fuel to our modeling efforts, with which we will produce a framework that can generalize to other sensory modalities, whenever decisions are based on a consideration of one stimulus at a time (even if two stimuli are present) rather than on a parallel processing of two or more stimuli simultaneously?that is, this novel framework will allow us to understand the behavior of animals when faced with a choice between any two separate stimuli. Thus, a transformative aspect of the research will be the development of a new framework for the analysis of decision-making when the choice to be made is whether to stick with the current stimulus or to switch to another. In such decision making tasks, which are ubiquitous in natural settings, the stimulus itself is chosen by the subject rather than being controled by the experimenter. Our recordings of the animal's behavior simultaneously with its neural activity allow us to tightly constrain these first dynamic models of such a process. Taste is an important, albeit underused, modality for addressing issues of sensory processing, in that it has a strong connection to behavior?indeed it is well-nigh impossible for an animal to sample a taste without a behavioral response. Moreover, given that tastants can be intrinisically hedonic or aversive, animals are internally driven to make responses and will do so without the months of training?which inevitably rewires the brain?required for animal training in behavioral tasks based on other sensory modalities. Therefore taste is ideally suited to the study of naturalistic decision making.

Public Health Relevance

These investigations of how sampling of one tastant can make another more or less desirable may have clinical implications, for instance, the treatment of some forms of obesity and the alleviation of childhood taste disorders caused by chemotherapy. Furthermore, insights into the nature of normal cortical activity underlying common behavioral choices should improve our understanding of its dysfunction in addictive disorders and disorders of executive control such as schizophrenia.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
David, Karen Kate
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brandeis University
Schools of Arts and Sciences
United States
Zip Code