Abstract

The long range objectives of this proposal are to develop and evaluate statistical techniques which are useful in the design and analysis of human studies arising in cancer research. Specific topics for the current funding period include: (1) distribution-free methods for comparing treatment groups with respect to repeated measures data in randomized clinical trials; (2) methods for detecting and controlling for overdispersion in censored survival data; and (3) estimator of odds ratios in case-control studies which incorporate distributional assumptions concerning exposure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA039640-07
Application #
3178895
Study Section
Special Emphasis Panel (SSS (B6))
Project Start
1985-06-01
Project End
1994-05-31
Budget Start
1991-06-01
Budget End
1992-05-31
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Murray, S; Tsiatis, A A (2001) Using auxiliary time-dependent covariates to recover information in nonparametric testing with censored data. Lifetime Data Anal 7:125-41
Lefkopoulou, M; Ryan, L (1993) Global tests for multiple binary outcomes. Biometrics 49:975-88
Hughes, M D (1993) Reporting Bayesian analyses of clinical trials. Stat Med 12:1651-63
Dawson, J D; Lagakos, S W (1993) Size and power of two-sample tests of repeated measures data. Biometrics 49:1022-32
Begg, M D; Lagakos, S (1990) On the consequences of model misspecification in logistic regression. Environ Health Perspect 87:69-75
Kim, M Y; Lagakos, S W (1990) Estimating the infectivity of HIV from partner studies. Ann Epidemiol 1:117-28
Lagakos, S W (1988) Effects of mismodelling and mismeasuring explanatory variables on tests of their association with a response variable. Stat Med 7:257-74
De Gruttola, V; Mayer, K H (1988) Assessing and modeling heterosexual spread of the human immunodeficiency virus in the United States. Rev Infect Dis 10:138-50
Day, R S (1986) Treatment sequencing, asymmetry, and uncertainty: protocol strategies for combination chemotherapy. Cancer Res 46:3876-85
Lagakos, S W; Mosteller, F (1986) Assigned shares in compensation for radiation-related cancers. Risk Anal 6:345-57