This proposal seeks to continue current studies in the synthesis of cytotoxic and antineoplastic natural products. New chemical methods are to be developed along with the preparation of substrates for biological evaluation. The completion of the synthesis of eriolanin and eriolangin is planned. Methods developed for the synthesis of aromatin will be applied to fastigilin-type pseudoguaianolides. Experience gained with the Cope-Claisen rearrangement will be utilized in the synthesis of the cytotoxic substance, quadrone. Finally, studies will be started which will be applicable to the synthesis of the antitumor substance, bruceantin.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039976-14
Application #
3179389
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1985-09-01
Project End
1990-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
14
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520