Since carotenoids have proven to be anticancer agents elucidation of the mechanism of their action is our ultimate goal. In order to achieve this we have to understand (a) how the carotenoids are absorbed across the gut, (b) what changes do they undergo and (c) how are they transported in circulation and distributed in various parts of the body. It would also be important to find out how these processes are affected when carotenoids are consumed in excess. We plan to systematically analyze all the above issues using rats as the experimental animals. We will use both whole animal and isolated enzyme systems to solve these questions. The knowledge gained in these investigations could lead to our understanding of carotenoid action in the treatment of cancer in man.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039999-02
Application #
3179416
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1987-04-01
Project End
1990-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
George Washington University
Department
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052