Abstract

This study attempts to test the hypothesis that involuntary exposure to tobacco smoke increases the risk of lung cancer. It is a population-based case-referent (control) study of women who never used tobacco products and develop lung cancer. Cases will be rapidly ascertained in five large metropolitan areas: New Orleans, Atlanta, San Francisco, Los Angeles, and Houston. There will be two separate control groups: non-smoking women who develop colon cancer reesiding in the same geographic area as the cases; and a population control group obtained by a random digit dialing protocol. Personal interviews at home will be conducted. The questionnaire will cover passive smoking exposures at home, at work, and in other areas; residential chracteristics; diet; and demographic information. Logistic regression techniques will be used in the analysis to examine risk of lung cancer associated with passive smoking while controlling for confounding variables. The data processing will be centralized in one of the participating centers, Atlanta, and the analysis will be a cooperative effort of the investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA040095-03S1
Application #
3179603
Study Section
(SSS)
Project Start
1985-09-01
Project End
1989-02-15
Budget Start
1987-09-01
Budget End
1989-02-15
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Type
School of Medicine & Dentistry
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Brennan, Paul; Buffler, Patricia A; Reynolds, Peggy et al. (2004) Secondhand smoke exposure in adulthood and risk of lung cancer among never smokers: a pooled analysis of two large studies. Int J Cancer 109:125-31
Wu, A H; Fontham, E T; Reynolds, P et al. (1996) Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States. Am J Epidemiol 143:535-42
Wu, A H; Fontham, E T; Reynolds, P et al. (1995) Previous lung disease and risk of lung cancer among lifetime nonsmoking women in the United States. Am J Epidemiol 141:1023-32
Fontham, E T; Correa, P; Reynolds, P et al. (1994) Environmental tobacco smoke and lung cancer in nonsmoking women. A multicenter study. JAMA 271:1752-9
Fontham, E T; Correa, P; Chen, V W (1993) Passive smoking and lung cancer. J La State Med Soc 145:132-6
Fontham, E T; Correa, P; WuWilliams, A et al. (1991) Lung cancer in nonsmoking women: a multicenter case-control study. Cancer Epidemiol Biomarkers Prev 1:35-43