Monoclonal antibodies to hormone and factor receptors of human cells will be produced. These will be used in various combinations to kill cancer cells in culture and to inhibit tumor growth in nude mice. Screening methods will be developed to search for hybridomas that produce high quantitites of high affinity antibodies to receptors. Screening and selection methods will be developed for searching for mutants which produce high levels of growth factors. Combinations of protein chemistry and recombinant DNA techniques will be used to characterize novel growth factors. (CS)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA040294-05
Application #
3180072
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1985-08-19
Project End
1990-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Adirondack Biomedical Research Institute
Department
Type
DUNS #
City
Lake Placid
State
NY
Country
United States
Zip Code
12946
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