Hyperthermia, when combined with radiation or drugs, has shown both in-vitro and in-vivo to have tremendous potential for human cancer therapy. Experience in our hyperthermia clinic treating 120 patients (1-12 heating sessions each) in which aggressive multipoint thermometry was used, revealed that tumors greater than 2-3 cm in any dimension are very rarely entirely heated to therapeutic temperatures (43-45 degrees C) with presently available equipment. The objective of this work is to develop microwave (MW) heating equipment that will allow more meaningful clinical studies of the efficacy of hyperthermia. A primary intent is to develop MW equipment capable of satisfactorily heating large area superficial (1-3 cm depth) tumors while keeping most of the adjacent normal tissue at 41 degrees C or below. Particular emphasis will be placed on the entire chest wall and axilla region. This equipment will be able to compensate for spatially and time varying conditions, and will couple to contoured surfaces. Development of applicators accessible to body cavities is included. An extensive study of the feasibility of using radiometry as a first step non-invasive temperature monitoring technique useful for power control with versatile surface applicators will be undertaken. Large MW applicators to improve deep heating will be developed. These will be based partly on the knowledge and techniques developed for superficial heating, and have primary concern for the realities of clinical treatments. Comprehensive evaluation techniques and analysis, employing phantoms, live animals (pigs) and clinical treatments will be developed and implemented to evaluate the equipment resulting from seven projects: 1) optimization of radiating microstrip antennae, 2) scanning superficial applicators, 3) MW """"""""blanket,"""""""" 4) versatile multi-element feedback phase and amplitude power control, 5) """"""""balloon"""""""" flexible intracavitary applicators, 6) radiometry-aided power control, and 7) deep heating development.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA040434-01
Application #
3180358
Study Section
Radiation Study Section (RAD)
Project Start
1986-03-15
Project End
1991-02-28
Budget Start
1986-03-15
Budget End
1987-02-28
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Kapp, D S; Cox, R S; Fessenden, P et al. (1992) Parameters predictive for complications of treatment with combined hyperthermia and radiation therapy. Int J Radiat Oncol Biol Phys 22:999-1008
Lee, E R; Wilsey, T R; Tarczy-Hornoch, P et al. (1992) Body conformable 915 MHz microstrip array applicators for large surface area hyperthermia. IEEE Trans Biomed Eng 39:470-83
Samulski, T V; Fessenden, P; Lee, E R et al. (1990) Spiral microstrip hyperthermia applicators: technical design and clinical performance. Int J Radiat Oncol Biol Phys 18:233-42
Kapp, D S (1989) Indications for the clinical use of deep local and regional hyperthermia in conjunction with radiation therapy. Strahlenther Onkol 165:724-8
Lyons, B E; Samulski, T V; Cox, R S et al. (1989) Heat loss and blood flow during hyperthermia in normal canine brain. I: Empirical study and analysis. Int J Hyperthermia 5:225-47
Samulski, T V; Cox, R S; Lyons, B E et al. (1989) Heat loss and blood flow during hyperthermia in normal canine brain. II: Mathematical model. Int J Hyperthermia 5:249-63
Valdagni, R; Liu, F F; Kapp, D S (1988) Important prognostic factors influencing outcome of combined radiation and hyperthermia. Int J Radiat Oncol Biol Phys 15:959-72
Knox, S J; Kapp, D S (1988) Hyperthermia and radiation therapy in the treatment of recurrent Merkel cell tumors. Cancer 62:1479-86
Kapp, D S; Prionas, S D; Fessenden, P et al. (1988) Bladder cooling in patients treated with regional hyperthermia of the pelvis using an annular phased array. Int J Radiat Oncol Biol Phys 14:1307-10