This project has the purpose of developing and studying the physical techniques needed for producing magnetic resonance images (MRI) of fluorinated compounds which can be injected into the bloodstream. Some such components have already reached a high state of development as blood substitutes, and are far less toxic than any other contrast agents used in radiography or MRI. Present fluorine MRI techniques, however, are not capable of producing high quality anatomic images of the vascular system under condition of field strength and scan time likely to be acceptable clinically; two of the primary reasons are the large NMR spectral widths of the compounds and the loss of signal due to the flow of the blood. We propose to explore several modifications of standard MRI pulse sequences and image reconstruction mathematics which promise to overcome these limitations. We also will explore the utility of imaging other fluorine compounds, as diagnostic contrast agents, which might not be acceptable as a life supporting blood substitutes. The various methods will be evaluated using computer simulation, experiments in phantoms using a 1.4 Tesla research MRI machine, and in preliminary in vivo experiments using rats, rabbits, and cats. The goal is to develop a technique which could be directly applied to fluorine angiography in humans. Non angiographic imaging applications will also be studied.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA040451-03
Application #
3180417
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1985-07-01
Project End
1988-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Lu, D; Joseph, P M (1995) A matched filter echo summation technique for MRI. Magn Reson Imaging 13:241-9
Meyer, K L; Joseph, P M; Mukherji, B et al. (1994) Demonstration of differences in vascular permeability in experimental tumors by use of 19F magnetic resonance imaging. Acad Radiol 1:106-13
Lu, D; Joseph, P M; Greenberg, J H et al. (1993) Use of 19F magnetic resonance imaging to measure local cerebral blood volume. Magn Reson Med 29:179-87
Meyer, K L; Joseph, P M; Mukherji, B et al. (1993) Measurement of vascular volume in experimental rat tumors by 19F magnetic resonance imaging. Invest Radiol 28:710-9
Meyer, K L; Carvlin, M J; Mukherji, B et al. (1992) Fluorinated blood substitute retention in the rat measured by fluorine-19 magnetic resonance imaging. Invest Radiol 27:620-7
Lu, D F; Joseph, P M (1991) A technique of double-resonant operation of 19F and 1H quadrature birdcage coils. Magn Reson Med 19:180-5
Mukherji, B; Sloviter, H A (1991) A stable perfluorochemical blood substitute. Transfusion 31:324-6
Saadi-Elmandjra, M; Joseph, P M; Noordergraaf, A (1990) Effect of interfacial tension on flow of fluorochemicals in the vasculature of the lung: a theoretical and experimental study. Ann Biomed Eng 18:623-7
Fishman, J E; Joseph, P M; Carvlin, M J et al. (1989) In vivo measurements of vascular oxygen tension in tumors using MRI of a fluorinated blood substitute. Invest Radiol 24:65-71
Joseph, P M; Shetty, A (1988) A comparison of selective saturation and selective echo chemical shift imaging techniques. Magn Reson Imaging 6:421-30

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