Basic research on the determinants of magnetic relaxation in cells is proposed with the specific aims of testing current models for water proton relaxation by freely rotating protein molecules, measuring the contributions of local microdynamic anisotropy on water proton relaxation in both the transverse and longitudinal directions, measuring the consequences of magnetic relaxation coupling between the water proton spin systems in tissues and the macromolecular components, measuring the charges in water relaxation rates as a function of time after tissue samples are excised from test animals, comparing relaxation times in test animals obtained with an in vivo imaging research spectrometer with those obtained on a conventional relaxation spectrometer, measuring the relaxation rate changes of different normal and malignant samples obtained to cover a variety of pathologies, and monitoring the effect of pre-experiment physiological stress on the fundamental parameters T1 and T2 in animals as a function of organ. This research will be conducted on a variety of instrumentation including a dedicated 60 MHz pulsed NMR relaxation spectrometer, a field cycling magnetic relaxation dispersion spectrometer, and an in vivo and imaging spectrometer operating a 2 T with a usable bore of 22 cm.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA040699-03
Application #
3181002
Study Section
(SSS)
Project Start
1985-07-01
Project End
1988-12-31
Budget Start
1987-07-01
Budget End
1988-12-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Ceckler, T L; Gibson, S L; Kennedy, S D et al. (1991) Hetergeneous tumour response to photodynamic therapy assessed by in vivo localised 31P NMR spectroscopy. Br J Cancer 63:916-22
Bryant, R G; Marill, K; Blackmore, C et al. (1990) Magnetic relaxation in blood and blood clots. Magn Reson Med 13:133-44
Marshall, E A; Listinsky, J J; Ceckler, T L et al. (1989) Magnetic resonance imaging using a ribbonator: hand and wrist. Magn Reson Med 9:369-78
Jackson, C L; Bryant, R G (1989) Carbon-13 NMR of glycogen: hydration response studied by using solids methods. Biochemistry 28:5024-8
Hornak, J P; Marshall, E; Szumowski, J et al. (1988) MRI of extremities using perforated single-turn solenoids. Magn Reson Med 7:442-8
Listinsky, J J; Bryant, R G (1988) Gastrointestinal contrast agents: a diamagnetic approach. Magn Reson Med 8:285-92
Hornak, J P; Szumowski, J; Bryant, R G (1988) Magnetic field mapping. Magn Reson Med 6:158-63
Miller, R K; Mattison, D R; Panigel, M et al. (1987) Kinetic assessment of manganese using magnetic resonance imaging in the dually perfused human placenta in vitro. Environ Health Perspect 74:81-91
Ceckler, T L; Bryant, R G; Hornak, J P (1987) Noise reduction in wide-bore magnets using a patient cage. Magn Reson Med 5:173-4
Hornak, J P; Szumowski, J; Bryant, R G (1987) Elementary single turn solenoids used as the transmitter and receiver in magnetic resonance imaging. Magn Reson Imaging 5:233-7

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