Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA041068-01S1
Application #
3181367
Study Section
Radiation Study Section (RAD)
Project Start
1985-05-01
Project End
1988-02-29
Budget Start
1987-12-01
Budget End
1988-02-29
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Chmura, S J; Dolan, M E; Cha, A et al. (2000) In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin Cancer Res 6:737-42
Advani, S J; Chung, S M; Yan, S Y et al. (1999) Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. Cancer Res 59:2055-8
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Seetharam, S; Staba, M J; Schumm, L P et al. (1999) Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation. Int J Oncol 15:769-73
Chung, T D; Mauceri, H J; Hallahan, D E et al. (1998) Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer. Cancer Gene Ther 5:344-9
Staba, M J; Mauceri, H J; Kufe, D W et al. (1998) Adenoviral TNF-alpha gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft. Gene Ther 5:293-300
Epperly, M; Bray, J; Kraeger, S et al. (1998) Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy. Gene Ther 5:196-208
Hanna, N N; Mauceri, H J; Wayne, J D et al. (1997) Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res 57:4205-9
Chmura, S J; Nodzenski, E; Beckett, M A et al. (1997) Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res 57:1270-5

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