Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA041556-07S1
Application #
3182176
Study Section
Pathology B Study Section (PTHB)
Project Start
1986-07-01
Project End
1995-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
7
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Xie, Wen; Aisner, Seena; Baredes, Soly et al. (2013) Alterations of Smad expression and activation in defining 2 subtypes of human head and neck squamous cell carcinoma. Head Neck 35:76-85
Cohen-Solal, Karine A; Merrigan, Kim T; Chan, Joseph L-K et al. (2011) Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition. Pigment Cell Melanoma Res 24:512-24
Tan, Antoinette R; Alexe, Gabriela; Reiss, Michael (2009) Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat 115:453-95
Bharathy, Savita; Xie, Wen; Yingling, Jonathan M et al. (2008) Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype. Cancer Res 68:1656-66
Padgett, Richard W; Reiss, Michael (2007) TGFbeta superfamily signaling: notes from the desert. Development 134:3565-9
Ge, Rongrong; Rajeev, Vaishali; Ray, Partha et al. (2006) Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res 12:4315-30
Subramanian, Gayathri; Schwarz, Roderich E; Higgins, Linda et al. (2004) Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res 64:5200-11
Xie, Wen; Bharathy, Savita; Kim, David et al. (2003) Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray analysis. Oncol Res 14:61-73
Liu, Chenghai; Gaca, Marianna D A; Swenson, E Scott et al. (2003) Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 278:11721-8
Xie, Wen; Mertens, Joachim C; Reiss, Daniel J et al. (2002) Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res 62:497-505

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