Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042465-08
Application #
2090745
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1987-07-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Washington State University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Fu, Y M; Yu, Z X; Pelayo, B A et al. (1999) Focal adhesion kinase-dependent apoptosis of melanoma induced by tyrosine and phenylalanine deficiency. Cancer Res 59:758-65
Pelayo, B A; Fu, Y M; Meadows, G G (1999) Inhibition of B16BL6 melanoma invasion by tyrosine and phenylalanine deprivation is associated with decreased secretion of plasminogen activators and increased plasminogen activator inhibitors. Clin Exp Metastasis 17:841-8
Fu, Y M; Li, Y Q; Meadows, G G (1998) Influence of tyrosine and phenylalanine limitation of cytotoxicity of chimeric TGF-alpha toxins on B16BL6 murine melanoma in vitro. Nutr Cancer 31:1-7
Fu, Y M; Yu, Z X; Ferrans, V J et al. (1997) Tyrosine and phenylalanine restriction induces G0/G1 cell cycle arrest in murine melanoma in vitro and in vivo. Nutr Cancer 29:104-13
Elstad, C A; Thrall, B D; Raha, G et al. (1996) Tyrosine and phenylalanine restriction sensitizes adriamycin-resistant P388 leukemia cells to adriamycin. Nutr Cancer 25:47-60
Uhlenkott, C E; Huijzer, J C; Cardeiro, D J et al. (1996) Attachment, invasion, chemotaxis, and proteinase expression of B16-BL6 melanoma cells exhibiting a low metastatic phenotype after exposure to dietary restriction of tyrosine and phenylalanine. Clin Exp Metastasis 14:125-37
Huijzer, J C; McFarland, M; Niles, R M et al. (1996) Phorbol 12-myristate 13-acetate enhances nm23 gene expression in murine melanocytes but not in syngeneic B16-BL6 melanoma variants. J Cell Physiol 166:487-94
Huijzer, J C; Uhlenkott, C E; Meadows, G G (1995) Differences in expression of metalloproteinases and plasminogen activators in murine melanocytes and B16 melanoma variants: lack of association with in vitro invasion. Int J Cancer 63:92-9
Elstad, C A; Meadows, G G; Aslakson, C J et al. (1994) Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction. Adv Exp Med Biol 354:171-83
Blanckaert, V D; Schelling, M E; Elstad, C A et al. (1993) Differential growth factor production, secretion, and response by high and low metastatic variants of B16BL6 melanoma. Cancer Res 53:4075-81

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