Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042736-02
Application #
3184267
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1979-04-01
Project End
1988-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Lawrence Berkeley National Laboratory
Department
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720

  Publications

Singer, B (1996) DNA damage: chemistry, repair, and mutagenic potential. Regul Toxicol Pharmacol 23:2-13
Rao, S; Chenna, A; Slupska, M et al. (1996) Replication of O4-methylthymine-containing oligonucleotides: effect of 3' and 5' flanking bases on formation and extension of O4-methylthymine . guanine basepairs. Mutat Res 356:179-85
Pongracz, K; Dosanjh, M K; Singer, B et al. (1994) Synthesis of a 25 base oligonucleotide containing a styrene oxide modification at the O6 position of 2'-deoxyguanosine at a defined site and incorporation studies of the similarly modified 2'-deoxyguanosine-5'-triphosphate. Carcinogenesis 15:1371-5
Dosanjh, M K; Chenna, A; Kim, E et al. (1994) All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase. Proc Natl Acad Sci U S A 91:1024-8
Dosanjh, M K; Loechler, E L; Singer, B (1993) Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations. Proc Natl Acad Sci U S A 90:3983-7
Dosanjh, M K; Menichini, P; Eritja, R et al. (1993) Both O4-methylthymine and O4-ethylthymine preferentially form alkyl T.G pairs that do not block in vitro replication in a defined sequence. Carcinogenesis 14:1915-9
Singer, B; Antoccia, A; Basu, A K et al. (1992) Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine. Proc Natl Acad Sci U S A 89:9386-90
Dosanjh, M K; Singer, B; Essigmann, J M (1991) Comparative mutagenesis of O6-methylguanine and O4-methylthymine in Escherichia coli. Biochemistry 30:7027-33
Rydberg, B; Dosanjh, M K; Singer, B (1991) Human cells contain protein specifically binding to a single 1,N6-ethenoadenine in a DNA fragment. Proc Natl Acad Sci U S A 88:6839-42
Dosanjh, M K; Galeros, G; Goodman, M F et al. (1991) Kinetics of extension of O6-methylguanine paired with cytosine or thymine in defined oligonucleotide sequences. Biochemistry 30:11595-9

Showing the most recent 10 out of 26 publications