Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042755-10
Application #
2090926
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1985-11-01
Project End
1999-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Ryder, Christopher B; McColl, Karen; Distelhorst, Clark W (2013) Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation. Biochem Biophys Res Commun 430:1283-8
Ryder, Christopher; McColl, Karen; Zhong, Fei et al. (2012) Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk. J Biol Chem 287:27863-75
Molitoris, Jason K; McColl, Karen S; Swerdlow, Sarah et al. (2011) Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes. J Biol Chem 286:30181-9
Distelhorst, Clark W; Bootman, Martin D (2011) Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease. Cell Calcium 50:234-41
Molitoris, Jason K; McColl, Karen S; Distelhorst, Clark W (2011) Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis. Mol Endocrinol 25:409-20
Harr, Michael W; McColl, Karen S; Zhong, Fei et al. (2010) Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes. Autophagy 6:912-21
Harr, M W; Caimi, P F; McColl, K S et al. (2010) Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia. Cell Death Differ 17:1381-91
Harr, Michael W; Rong, Yiping; Bootman, Martin D et al. (2009) Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors. J Biol Chem 284:31860-71
Rong, Yi-Ping; Barr, Paul; Yee, Vivien C et al. (2009) Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor. Biochim Biophys Acta 1793:971-8
Rong, Yi-Ping; Aromolaran, Ademuyiwa S; Bultynck, Geert et al. (2008) Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell 31:255-65

Showing the most recent 10 out of 43 publications