Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043187-08
Application #
2091109
Study Section
Experimental Immunology Study Section (EI)
Project Start
1986-08-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
National Jewish Health
Department
Type
DUNS #
City
Denver
State
CO
Country
United States
Zip Code
80206

  Publications

Cook, J L; Routes, B A; Walker, T A et al. (1999) E1A oncogene induction of cellular susceptibility to killing by cytolytic lymphocytes through target cell sensitization to apoptotic injury. Exp Cell Res 251:414-23
Cook, J L; Routes, B A; Leu, C Y et al. (1999) E1A oncogene-induced cellular sensitization to immune-mediated apoptosis is independent of p53 and resistant to blockade by E1B 19 kDa protein. Exp Cell Res 252:199-210
Cook, J L; Potter, T A; Bellgrau, D et al. (1996) E1A oncogene expression in target cells induces cytolytic susceptibility at a post-recognition stage in the interaction with killer lymphocytes. Oncogene 13:833-42
Cook, J L; Krantz, C K; Routes, B A (1996) Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejection. Proc Natl Acad Sci U S A 93:13985-90
Routes, J M; Cook, J L (1995) E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells. Virology 210:421-8
Cook, J L; Ikle, D N; Routes, B A (1995) Natural killer cell ontogeny in the athymic rat. Relationship between functional maturation and acquired resistance to E1A oncogene-expressing sarcoma cells. J Immunol 155:5512-8
Routes, J M; Metz, B A; Cook, J L (1993) Endogenous expression of E1A in human cells enhances the effect of adenovirus E3 on class I major histocompatibility complex antigen expression. J Virol 67:3176-81
Routes, J M; Bellgrau, D; McGrory, W J et al. (1991) Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene. J Virol 65:1450-7
Walker, T A; Wilson, B A; Lewis Jr, A M et al. (1991) E1A oncogene induction of cytolytic susceptibility eliminates sarcoma cell tumorigenicity. Proc Natl Acad Sci U S A 88:6491-5
Routes, J M; Cook, J L (1990) Resistance of human cells to the adenovirus E3 effect on class I MHC antigen expression. Implications for antiviral immunity. J Immunol 144:2763-70

Showing the most recent 10 out of 14 publications