Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043659-02
Application #
3185946
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1987-01-01
Project End
1991-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Lin, T S; Zhu, L Y; Xu, S P et al. (1991) Synthesis and antimalarial activity of 2-aziridinyl- and 2,3-bis(aziridinyl)-1,4-naphthoquinonyl sulfonate and acylate derivatives. J Med Chem 34:1634-9
Saari, W S; Schwering, J E; Lyle, P A et al. (1991) Synthesis and evaluation of some nitrobenzenesulfonamides containing nitroisopropyl and (ureidooxy)methyl groups as novel hypoxic cell selective cytotoxic agents. J Med Chem 34:3132-8
Keyes, S R; Loomis, R; DiGiovanna, M P et al. (1991) Cytotoxicity and DNA crosslinks produced by mitomycin analogs in aerobic and hypoxic EMT6 cells. Cancer Commun 3:351-6
Tomasz, M; Hughes, C S; Chowdary, D et al. (1991) Isolation, identification, and assay of [3H]-porfiromycin adducts of EMT6 mouse mammary tumor cell DNA: effects of hypoxia and dicumarol on adduct patterns. Cancer Commun 3:213-23
Keyes, S R; Rockwell, S; Kennedy, K A et al. (1991) Distribution of porfiromycin in EMT6 solid tumors and normal tissues of BALB/c mice. J Natl Cancer Inst 83:632-7
Rockwell, S; Keyes, S R; Loomis, R et al. (1991) Activity of C-7 substituted cyclic acetal derivatives of mitomycin C and porfiromycin against hypoxic and oxygenated EMT6 carcinoma cells in vitro and in vivo. Cancer Commun 3:191-8
Rockwell, S; Keyes, S R; Sartorelli, A C (1989) Modulation of the antineoplastic efficacy of mitomycin C by dicoumarol in vivo. Cancer Chemother Pharmacol 24:349-53
Rockwell, S; Keyes, S R; Sartorelli, A C (1989) Modulation of the cytotoxicity of porfiromycin by dicoumarol in vitro and in vivo. Anticancer Res 9:817-20
Lin, T S; Xu, S P; Zhu, L Y et al. (1989) Synthesis of 2,3-diaziridinyl-1,4-naphthoquinone sulfonate derivatives as potential antineoplastic agents. J Med Chem 32:1467-71
Pritsos, C A; Keyes, S R; Sartorelli, A C (1989) Effect of the superoxide dismutase inhibitor, diethyldithiocarbamate, on the cytotoxicity of mitomycin antibiotics. Cancer Biochem Biophys 10:289-98

Showing the most recent 10 out of 15 publications