Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043803-10
Application #
2091269
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1987-01-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1998-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Laham, L E; Mukhopadhyay, N; Roberts, T M (2000) The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity. Oncogene 19:3961-70
King, F J; Hu, E; Harris, D F et al. (1999) DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Mol Cell Biol 19:2330-7
Adachi-Yamada, T; Nakamura, M; Irie, K et al. (1999) p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis. Mol Cell Biol 19:2322-9
Xia, K; Lee, R S; Narsimhan, R P et al. (1999) Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. Mol Cell Biol 19:4819-24
Batt, D B; Roberts, T M (1998) Cell density modulates protein-tyrosine phosphorylation. J Biol Chem 273:3408-14
Xia, K; Mukhopadhyay, N K; Inhorn, R C et al. (1996) The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Proc Natl Acad Sci U S A 93:11681-6
Nam, H J; Haser, W G; Roberts, T M et al. (1996) Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism. Structure 4:1105-14
Agarwal, S; Corbley, M J; Roberts, T M (1995) Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. Oncogene 11:427-38
Carrera, A C; Paradis, H; Borlado, L R et al. (1995) Lck unique domain influences Lck specificity and biological function. J Biol Chem 270:3385-91
Carrera, A C; Borlado, L R; Gonzalez-Garcia, A et al. (1995) Role of the autophosphorylation site on the biological function of pp56lck. Oncogene 10:2379-86

Showing the most recent 10 out of 30 publications