Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA043830-05S1
Application #
3186204
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1985-12-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Clapper, M L; Kuzmich, S; Seestaller, L M et al. (1993) Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure. Biochem Pharmacol 45:683-90
Kuzmich, S; Vanderveer, L A; Walsh, E S et al. (1992) Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid. Biochem J 281 ( Pt 1):219-24
Clapper, M L; Hoffman, S J; Carp, N et al. (1991) Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue. Carcinogenesis 12:1957-61
Clapper, M L; Hoffman, S J; Tew, K D (1991) Glutathione S-transferases in normal and malignant human colon tissue. Biochim Biophys Acta 1096:209-16
Morris, D I; Speicher, L A; Ruoho, A E et al. (1991) Interaction of forskolin with the P-glycoprotein multidrug transporter. Biochemistry 30:8371-9
Kuzmich, S; Vanderveer, L A; Tew, K D (1991) Evidence for a glycoconjugate form of glutathione S-transferase pI. Int J Pept Protein Res 37:565-71
Ranganathan, S; Tew, K D (1991) Immunohistochemical localization of glutathione S-transferases alpha, mu, and pi in normal tissue and carcinomas from human colon. Carcinogenesis 12:2383-7
Nakagawa, K; Saijo, N; Tsuchida, S et al. (1990) Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines. J Biol Chem 265:4296-301
Schisselbauer, J C; Silber, R; Papadopoulos, E et al. (1990) Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients. Cancer Res 50:3562-8
Clapper, M L; Tew, K D (1989) Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards. Biochem Pharmacol 38:1915-21

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