Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043894-07
Application #
3186351
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1986-04-01
Project End
1992-07-31
Budget Start
1992-03-01
Budget End
1992-07-31
Support Year
7
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of North Texas
Department
Type
Schools of Osteopathy
DUNS #
110091808
City
Fort Worth
State
TX
Country
United States
Zip Code
76107
Benavente, Claudia A; Schnell, Stephanie A; Jacobson, Elaine L (2012) Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. PLoS One 7:e42276
Tome, Margaret E; Frye, Jennifer B; Coyle, Donna L et al. (2012) Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance. Exp Ther Med 3:845-852
Bermudez, Yira; Benavente, Claudia A; Meyer, Ralph G et al. (2011) Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. PLoS One 6:e20487
Steffen, Jamin D; Coyle, Donna L; Damodaran, Komath et al. (2011) Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem 54:5403-13
Botta, Davide; Jacobson, Myron K (2010) Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase. Biochemistry 49:7674-82
Williams, Joshua D; Jacobson, Myron K (2010) Photobiological implications of folate depletion and repletion in cultured human keratinocytes. J Photochem Photobiol B 99:49-61
Whatcott, Clifford J; Meyer-Ficca, Mirella L; Meyer, Ralph G et al. (2009) A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp Cell Res 315:3477-85
Benavente, Claudia A; Jacobson, Myron K; Jacobson, Elaine L (2009) NAD in skin: therapeutic approaches for niacin. Curr Pharm Des 15:29-38
Young, Genevieve S; Kirkland, James B (2008) The role of dietary niacin intake and the adenosine-5'-diphosphate-ribosyl cyclase enzyme CD38 in spatial learning ability: is cyclic adenosine diphosphate ribose the link between diet and behaviour? Nutr Res Rev 21:42-55
Benavente, Claudia A; Jacobson, Elaine L (2008) Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes. Free Radic Biol Med 44:527-37

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