We have developed a water calorimeter which has the following immediate advantages (1) the dose is measured in the recommended medium of water; and (2) the calorimeter is simple in concept and operation. We have also developed a direct voltage-measurement technique using a digital voltmeter which has greatly simplified the monitoring of the calorimeter and made it possible to achieve digital data processing by a computer. The objective is to develop an instrument for the determination of absorbed dose. We intend to further develop a number of capabilities by means of: (1) a pulsed calorimeter to gain 25-fold increase in sensitivity by increasing the pulsed voltage for the same average heat consumption as that with the conventional DC technique; and (2) a mini-computer linkage for interactive operations and real-time data analysis. The goal is to construct a portable calorimeter for instant absorbed dose determination and to establish it as the absolute absorbed dose detector: 1) We intend to use this portable calorimeter for a variety of radiation beams Co-60 gamma rays, 4, 6 and 18 MV x-rays, and 12 and 20 MeV electron beams; 2) We intend to use the calorimeter for non-conventional beams; proton and neutron beams, where the dose discrepancies were reported to be as large as 10% among different dosimeters; 3) We intend to determine the heat defect of water by absorbed dose comparison between water and polystyrene-water calorimeters; 4) We intend to establish a standard data analysis method for a polystyrene-water calorimeter, which has a troublesome upward concave shape during post-irradiation drifts. If this program demonstrates the advantage of a high sensitivity pulsed calorimeter, it will provide an important step toward determining the absolute absorbed dose which is fundamental in radiation therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA044054-04
Application #
3186575
Study Section
Project Start
1987-04-01
Project End
1990-12-31
Budget Start
1988-12-01
Budget End
1990-12-31
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627