Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA044499-09
Application #
2091497
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1986-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Pharmacology
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Li, Qiong; Wright, Stephen E; Matijasevic, Zdenka et al. (2003) The role of human alkyladenine glycosylase in cellular resistance to the chloroethylnitrosoureas. Carcinogenesis 24:589-93
Ludlum, D B; Li, Q; Matijasevic, Z (1999) Role of base excision repair in protecting cells from the toxicity of chloroethylnitrosoureas. IARC Sci Publ :271-7
Ludlum, D B (1997) The chloroethylnitrosoureas: sensitivity and resistance to cancer chemotherapy at the molecular level. Cancer Invest 15:588-98
Matijasevic, Z; Boosalis, M; Mackay, W et al. (1993) Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase. Proc Natl Acad Sci U S A 90:11855-9
Niu, T; Yu, D; Kirk, M C et al. (1993) Synthesis of the prototype DNA-protein cross-link, 1-(guan-1-yl)-2-(cysteine-S-yl)ethane, and its role in the reactions of the haloethylnitrosoureas. Carcinogenesis 14:195-8
Matijasevic, Z; Sekiguchi, M; Ludlum, D B (1992) Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II. Proc Natl Acad Sci U S A 89:9331-4
Ludlum, D B; Habraken, Y; Carter, C A et al. (1992) The formation and enzymatic repair of DNA modifications caused by the haloethylnitrosoureas and related compounds. Nucleic Acids Symp Ser :25-6
Gonzaga, P E; Potter, P M; Niu, T Q et al. (1992) Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA. Cancer Res 52:6052-8
Habraken, Y; Carter, C A; Sekiguchi, M et al. (1991) Release of N2,3-ethanoguanine from haloethylnitrosourea-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II. Carcinogenesis 12:1971-3
Matijasevic, Z; Bodell, W J; Ludlum, D B (1991) 3-Methyladenine DNA glycosylase activity in a glial cell line sensitive to the haloethylnitrosoureas in comparison with a resistant cell line. Cancer Res 51:1568-70

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