Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA045156-08
Application #
2091761
Study Section
Radiation Study Section (RAD)
Project Start
1987-07-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Kalia, V K; Al-Nabulsi, I; Wallen, C A et al. (2000) Radiation-induced DNA damage in tumors and normal tissues. VI. Estimation of the hypoxic fraction of experimental tumors. Radiat Res 153:548-56
Xu, L; Tay, C H; Huber, B T et al. (2000) Cloning of an infectious milk-borne mouse mammary tumor virus (MMTV) DNA from a mammary tumor that developed in an endogenous MMTV-free wild mouse. Virology 273:325-32
Al-Nabulsi, I; Wheeler, K T (1999) Radiation-induced DNA damage in tumors and normal tissues: V. Influence of pH and nutrient depletion on the formation of DNA-protein crosslinks in irradiated partially and fully hypoxic tumor cells. Radiat Res 151:188-94
Kalandarishvili, F; Wheeler, K T (1999) Accumulation of DNA damage in pre- and posthepatectomized liver of aged rats. Mech Ageing Dev 110:25-35
Mach, R H; Smith, C R; al-Nabulsi, I et al. (1997) Sigma 2 receptors as potential biomarkers of proliferation in breast cancer. Cancer Res 57:156-61
Al-Nabulsi, I; Wheeler, K T (1997) Temperature dependence of radiation-induced DNA-protein crosslinks formed under hypoxic conditions. Radiat Res 148:568-74
Miyagi, Y; Zhang, H; Wheeler, K T (1997) Radiation-induced DNA damage in tumors and normal tissues: IV. Influence of proliferation status and cell type on the formation of oxygen-dependent DNA damage in cultured cells. Radiat Res 148:29-34
Zhang, H; Wheeler, K T (1996) Influence of topoisomerase II on the formation of oxygen-dependent radiation-induced DNA damage. Br J Cancer Suppl 27:S196-9
Swarts, S G; Smith, G S; Miao, L et al. (1996) Effects of formic acid hydrolysis on the quantitative analysis of radiation-induced DNA base damage products assayed by gas chromatography/mass spectrometry. Radiat Environ Biophys 35:41-53
Zhang, H; Koch, C J; Wallen, C A et al. (1995) Radiation-induced DNA damage in tumors and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA-protein crosslinks. Radiat Res 142:163-8

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