The aim of this proposal is to investigate multiparametric nuclear magnetic resonance (NMR) imaging techniques, especially related to flow quantification. The research effort will be concentrated in the areas of: image reconstruction algorithms, methods and systems necessary for imaging a three dimensional volume. The variables which will be explored are diffusion, random directional perfusive flow and coherent bulk flow. In addition, techniques for measuring the distribution functions describing coherent and incoherent flow will be developed. Higher order motion related parameters such as acceleration and jerk (which is the rate of change of acceleration) will also be investigated. The flow measurement techniques will be combined with high speed imaging methods to enable one to reduce the required data acquisition time. The successful completion of this proposal would enable scientists and clinicians to measure and characterize both diffusive and perfusive blood flow accurately. Furthermore, three dimensional images of blood perfusion through the capillary bed will be investigated in conjunction with other existing imaging techniques such as positron emission tomography. Diffusive and coherent bulk flow will be investigated in connection with molecular biology and physics where established methods and results are readily available.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
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Diagnostic Radiology Study Section (RNM)
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University of California Irvine
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Guclu, C; Kashmar, G; Hacinliyan, A et al. (1997) An FEM approach for the characterization of the RF field homogeneity at high field. Magn Reson Med 37:76-83
Su, M Y; Najafi, A A; Nalcioglu, O (1995) Regional comparison of tumor vascularity and permeability parameters measured by albumin-Gd-DTPA and Gd-DTPA. Magn Reson Med 34:402-11
Su, M Y; Jao, J C; Nalcioglu, O (1994) Measurement of vascular volume fraction and blood-tissue permeability constants with a pharmacokinetic model: studies in rat muscle tumors with dynamic Gd-DTPA enhanced MRI. Magn Reson Med 32:714-24
Su, M Y; Nalcioglu, O (1993) Susceptibility effects in porous media in the presence of flow. J Magn Reson Imaging 3:794-9
Vu, A T; Lee, H K; Moran, P R et al. (1993) Flow field mapping by multi-zone adiabatic passage excitation. Magn Reson Imaging 11:1129-37
Su, M Y; Nalcioglu, O (1993) Statistical description of microcirculatory flow as measured with an MR method. J Magn Reson Imaging 3:883-7
Lee, H K; Nalcioglu, O; Buxton, R B (1992) Correction of chemical-shift artifacts in 19F imaging of PFOB: a robust signed magnitude method. Magn Reson Med 23:254-63
Lee, H K; Nalcioglu, O (1992) Reduced-bandwidth method for F-19 imaging of perflubron. J Magn Reson Imaging 2:563-8
Lee, H K; Nalcioglu, O (1992) Reblurred deconvolution method for chemical shift removal in F-19 (PFOB) MR imaging. J Magn Reson Imaging 2:53-61
Ozdemirel, B; Nalcioglu, O (1992) Correction of chemical-shift artifacts in multislice F-19 imaging with perfluorooctyl bromide. Magn Reson Med 23:324-32

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