Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA045557-01
Application #
3188660
Study Section
Radiation Study Section (RAD)
Project Start
1987-08-15
Project End
1992-07-31
Budget Start
1987-08-15
Budget End
1988-07-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Wang, Y; Cheong, N; Iliakis, G (1993) Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporine. Cancer Res 53:1213-7
Cheong, N; Wang, Y; Iliakis, G (1993) Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras plus v-myc is cell cycle dependent and maximal during S and G2. Int J Radiat Biol 63:623-9
Iliakis, G E; Pantelias, G E; Okayasu, R et al. (1992) Induction by H2O2 of DNA and interphase chromosome damage in plateau-phase Chinese hamster ovary cells. Radiat Res 131:192-203
Wang, Y; Iliakis, G (1992) Prolonged inhibition by X-rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with oncogenes H-ras and v-myc. Cancer Res 52:508-14
Iliakis, G; Wang, Y; Pantelias, G E et al. (1992) Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on repair of DNA breaks, interphase chromatin breaks, and potentially lethal damage in plateau-phase CHO cells. Radiat Res 129:202-11
Iliakis, G; Mehta, R; Jackson, M (1992) Level of DNA double-strand break rejoining in Chinese hamster xrs-5 cells is dose-dependent: implications for the mechanism of radiosensitivity. Int J Radiat Biol 61:315-21
Okayasu, R; Iliakis, G (1992) The shape of DNA elution dose-response curves under non-denaturing conditions: the contribution of the degree of chromatin condensation. Int J Radiat Biol 61:455-63
Cheong, N; Wang, Y; Jackson, M et al. (1992) Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delay. Mutat Res 274:111-22
Iliakis, G E; Metzger, L; Denko, N et al. (1991) Detection of DNA double-strand breaks in synchronous cultures of CHO cells by means of asymmetric field inversion gel electrophoresis. Int J Radiat Biol 59:321-41
Iliakis, G; Pantelias, G; Kurtzman, S (1991) Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on cell killing and interphase chromosome breakage in radiation-sensitive cells. Radiat Res 125:56-64

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