Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA045734-03
Application #
3188975
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1989-01-12
Project End
1992-11-30
Budget Start
1989-01-12
Budget End
1989-11-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Billings, P C; Maki, P A; Kennedy, A R (1994) Effect of modifiers of arachidonic acid metabolism on radiation transformation and eicosanoid formation in C3H/10T1/2 cells. Cancer Biochem Biophys 14:211-20
Hughes, E N; Engelsberg, B N; Billings, P C (1992) Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1 and 2. J Biol Chem 267:13520-7
Billings, P C; Habres, J M (1992) A growth-regulated protease activity that is inhibited by the anticarcinogenic Bowman-Birk protease inhibitor. Proc Natl Acad Sci U S A 89:3120-4
Habres, J M; Billings, P C (1992) Intestinal epithelial cells contain a high molecular weight protease subject to inhibition by anticarcinogenic protease inhibitors. Cancer Lett 63:135-42
Billings, P C; St Clair, W H; Maki, P A et al. (1992) Distribution of the Bowman Birk protease inhibitor in mice following oral administration. Cancer Lett 62:191-7
Billings, P C; Davis, R J; Engelsberg, B N et al. (1992) Characterization of high mobility group protein binding to cisplatin-damaged DNA. Biochem Biophys Res Commun 188:1286-94
Billings, P C; Jin, T; Ohnishi, N et al. (1991) The interaction of the potato-derived chymotrypsin inhibitor with C3H/10T1/2 cells. Carcinogenesis 12:653-7
Billings, P C; Brandon, D L; Habres, J M (1991) Internalisation of the Bowman-Birk protease inhibitor by intestinal epithelial cells. Eur J Cancer 27:903-8
Billings, P C; Habres, J M; Liao, D C et al. (1991) Human fibroblasts contain a proteolytic activity which is inhibited by the Bowman-Birk protease inhibitor. Cancer Res 51:5539-43
Billings, P C; Habres, J M; Kennedy, A R (1990) Inhibition of radiation-induced transformation of C3H/10T1/2 cells by specific protease substrates. Carcinogenesis 11:329-32

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