Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA045957-01
Application #
3189225
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1987-06-01
Project End
1990-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101
Cheng, Guoyan; Yu, Aixin; Dee, Michael J et al. (2013) IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development. J Immunol 190:1567-75
Cheng, Guoyan; Yuan, Xiaomei; Tsai, Matthew S et al. (2012) IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol 189:1780-91
Yuan, Xiaomei; Malek, Thomas R (2012) Cellular and molecular determinants for the development of natural and induced regulatory T cells. Hum Immunol 73:773-82
Cheng, Guoyan; Yu, Aixin; Malek, Thomas R (2011) T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev 241:63-76
Malek, Thomas R; Castro, Iris (2010) Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 33:153-65
Yu, Aixin; Zhu, Linjian; Altman, Norman H et al. (2009) A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 30:204-17
Bayer, Allison L; Lee, Joon Youb; de la Barrera, Anabel et al. (2008) A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol 181:225-34
Yu, Aixin; Malek, Thomas R (2006) Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells. J Immunol 177:5115-21
Adeegbe, Dennis; Bayer, Allison L; Levy, Robert B et al. (2006) Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. J Immunol 176:7149-53
Jin, Haoli; Carrio, Roberto; Yu, Aixin et al. (2004) Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 173:657-65

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