The hypothesis to be tested in the continuation of this collaborative project is that phototherapy is applicable to the treatment of highly pigmented tumors such as cutaneous malignant melanoma (CMM). This hypothesis is to be evaluated by (a) establishing the limits of photodynamic therapy (PDT) in pigmented tumors, (b)establishing whether PDT can be applied to melanotic tumors that have been prebleached by high- peak-power light, and (c) establishing the usefulness of photothermal therapy (PTT) to such tumors. The hypothesis will be tested by synthesizing a series of near-IR-light absorbing photosensitizing compounds for PDT and for HT and assaying their effectiveness. Compounds to be synthesized will be metallo-centered naphthalocyanines having various axial and peripheral substituents that will provide solubility and tumor retention modifications. Photophysical measurements will address questions about the nature, lifetime, and deactivation modes of low-lying electronic states and will assist in characterizing the capabilities of the compounds to act in the PDT and HT modes. Pharmacokinetic studies will address the distribution of potential sensitizers for PDT and HT within murine systems (B16 malignant melanoma); and phototherapeutic tests will determine the effectiveness of the various sensitizers and allow the design of protocols for clinical evaluation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046281-09
Application #
2458056
Study Section
Special Emphasis Panel (ZRG3-RAD (01))
Program Officer
Mahoney, Francis J
Project Start
1988-09-01
Project End
1999-07-31
Budget Start
1997-08-01
Budget End
1999-07-31
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Bowling Green State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
617407325
City
Bowling Green
State
OH
Country
United States
Zip Code
43403
Aoudia, M; Guliaev, A B; Leontis, N B et al. (2000) Self-assembled complexes of oligopeptides and metalloporphyrins: measurements of the reorganization and electronic interaction energies for photoinduced electron-transfer reactions. Biophys Chem 83:121-40
Zuk, M M; Rihter, B D; Kenney, M E et al. (1994) Pharmacokinetic and tissue distribution studies of the photosensitizer bis(di-isobutyl octadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) in normal and tumor-bearing rats. Photochem Photobiol 59:66-72
Biolo, R; Jori, G; Soncin, M et al. (1994) Photodynamic therapy of B16 pigmented melanoma with liposome-delivered Si(IV)-naphthalocyanine. Photochem Photobiol 59:362-5
Rodgers, M A (1993) Reflections on type I photodynamic damage. J Photochem Photobiol B 18:296-8
Oleinick, N L; Antunez, A R; Clay, M E et al. (1993) New phthalocyanine photosensitizers for photodynamic therapy. Photochem Photobiol 57:242-7
Bellemo, C; Jori, G; Rihter, B D et al. (1992) Si(IV)-naphthalocyanine: modulation of its pharmacokinetic properties through the use of hydrophilic axial ligands. Cancer Lett 65:145-50
Rihter, B D; Bohorquez, M D; Rodgers, M A et al. (1992) Two new sterically hindered phthalocyanines: synthetic and photodynamic aspects. Photochem Photobiol 55:677-80
Zuk, M M; Rihter, B D; Kenney, M E et al. (1991) Photosensitizers for tumor therapy: determination of bis(di-isobutyl octadecylsiloxy)silicon 2,3-naphthalocyanine (isoBOSINC) in rat tissue and serum by high-performance liquid chromatography. J Chromatogr 568:437-44
Cuomo, V; Jori, G; Rihter, B et al. (1991) Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine. Br J Cancer 64:93-5
Cuomo, V; Jori, G; Rihter, B et al. (1990) Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies. Br J Cancer 62:966-70

Showing the most recent 10 out of 11 publications