Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA046657-01A1
Application #
3190012
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-08-01
Project End
1993-05-31
Budget Start
1988-08-01
Budget End
1989-05-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Clarke, M F; Apel, I J; Benedict, M A et al. (1995) A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proc Natl Acad Sci U S A 92:11024-8
Schott, A F; Apel, I J; Nunez, G et al. (1995) Bcl-XL protects cancer cells from p53-mediated apoptosis. Oncogene 11:1389-94
Ryan, J J; Clarke, M F (1994) Alteration of p53 conformation and induction of apoptosis in a murine erythroleukemia cell line by dimethylsulfoxide. Leuk Res 18:617-21
Ryan, J J; Prochownik, E; Gottlieb, C A et al. (1994) c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci U S A 91:5878-82
Ryan, J J; Danish, R; Gottlieb, C A et al. (1993) Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells. Mol Cell Biol 13:711-9
Danish, R; el-Awar, O; Weber, B L et al. (1992) c-myb effects on kinetic events during MEL cell differentiation. Oncogene 7:901-7
Angelotti, T P; Clarke, M F; Longino, M A et al. (1991) Biotinylated granulocyte/macrophage colony-stimulating factor analogues: effect of linkage chemistry on activity and binding. Bioconjug Chem 2:466-74
Weber, B L; Westin, E H; Clarke, M F (1990) Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA. Science 249:1291-3