Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA047304-03S1
Application #
3190854
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-04-01
Project End
1991-03-31
Budget Start
1990-07-01
Budget End
1991-03-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Lee, T H; Wisniewski, H G; Vilcek, J (1992) A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J Cell Biol 116:545-57
Vilcek, J; Palombella, V J (1992) TNF as a growth factor. Immunol Ser 56:269-87
Vilcek, J; Lee, T H (1991) Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J Biol Chem 266:7313-6
Gase, K; Korobko, V G; Wisniewski, H G et al. (1990) Critical role of the C-terminus in the biological activities of human tumour necrosis factor-alpha. Immunology 71:368-71
Zhang, Y H; Lin, J X; Vilcek, J (1990) Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol Cell Biol 10:3818-23
Aderka, D; Le, J M; Vilcek, J (1989) IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. J Immunol 143:3517-23
Palombella, V J; Vilcek, J (1989) Mitogenic and cytotoxic actions of tumor necrosis factor in BALB/c 3T3 cells. Role of phospholipase activation. J Biol Chem 264:18128-36
Reis, L F; Ho Lee, T; Vilcek, J (1989) Tumor necrosis factor acts synergistically with autocrine interferon-beta and increases interferon-beta mRNA levels in human fibroblasts. J Biol Chem 264:16351-4
Le, J M; Fredrickson, G; Pollack, M et al. (1989) Activation of thymocytes and T cells by interleukin-6. Ann N Y Acad Sci 557:444-52;discussion 452-3
Zhang, Y H; Lin, J X; Yip, Y K et al. (1988) Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Proc Natl Acad Sci U S A 85:6802-5