Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA047786-07
Application #
2092747
Study Section
Radiation Study Section (RAD)
Project Start
1989-12-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Biology
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Klostergaard, J; Leroux, M E; Auzenne, E et al. (2006) Hyperthermia engages the intrinsic apoptotic pathway by enhancing upstream caspase activation to overcome apoptotic resistance in MCF-7 breast adenocarcinoma cells. J Cell Biochem 98:356-69
Leroux, E; Auzenne, E; Weidner, D et al. (2001) Febrile and acute hyperthermia enhance TNF-induced necrosis of murine L929 fibrosarcoma cells via caspase-regulated production of reactive oxygen intermediates. J Cell Physiol 187:256-63
Wang, G; Klostergaard, J; Khodadadian, M et al. (1996) Murine cells transfected with human Hsp27 cDNA resist TNF-induced cytotoxicity. J Immunother Emphasis Tumor Immunol 19:9-20
Klostergaard, J; Akimaru, Y; Tomasovic, S P (1996) Step-down heating enhances the cytotoxicity of human tumour necrosis factor on murine and human tumour cell lines in vitro. Int J Hyperthermia 12:97-114
Klostergaard, J; Leroux, M E; Tomasovic, S P (1995) Clonogenic survival studies of human colon tumor cell lines in vitro: combined hyperthermia, 5-fluorouracil/leucovorin, carboplatin and tumor necrosis factor. Radiat Res 141:44-8
Tomasovic, S P; Khodadadian, M; Hung, M C et al. (1994) Hyperthermia enhances the cytotoxicity of National Institutes of Health 3T3 cells transfected with a noncleavable transmembrane pro-tumor necrosis factor deletion mutant. J Immunother Emphasis Tumor Immunol 16:181-7
Tomasovic, S P; Vasey, T A; Story, M D et al. (1994) Cytotoxic manifestations of the interaction between hyperthermia and TNF: DNA fragmentation. Int J Hyperthermia 10:247-62
Tomasovic, S P; Lu, S; Klostergaard, J (1992) Comparative in vitro studies of the potentiation of tumor necrosis factor (TNF)-alpha, TNF-beta, and TNF-SAM2 cytotoxicity by hyperthermia. J Immunother (1991) 11:85-92
Klostergaard, J; Leroux, E; Siddik, Z H et al. (1992) Enhanced sensitivity of human colon tumor cell lines in vitro in response to thermochemoimmunotherapy. Cancer Res 52:5271-7
Tomasovic, S P; Klostergaard, J (1991) Bacterial endotoxin lipopolysaccharide modulates synthesis of the 70 kDa heat stress protein family. Int J Hyperthermia 7:643-51