Transformation and Differentiation by V and C Abl Genes

Reddy, E Premkumar

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 7R01CA047937-05
• Application #: 3191763
• Study Section: Molecular Cytology Study Section (CTY)
• Project Start: 1988-07-01
• Project End: 1993-05-31
• Budget Start: 1992-02-01
• Budget End: 1992-05-31
• Support Year: 5
• Fiscal Year: 1991

Institution

• Name: Temple University
• Type: Schools of Medicine
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19122

Publications

Shore, S K; La Cava, M; Yendapalli, S et al. (1994) Structural alterations in the carboxyl-terminal domain of the BCRABL gene product activate its fibroblastic transforming potential. J Biol Chem 269:5413-9

Shore, S K; Nabissa, P M; Reddy, E P (1993) Ribozyme-mediated cleavage of the BCRABL oncogene transcript: in vitro cleavage of RNA and in vivo loss of P210 protein-kinase activity. Oncogene 8:3183-8

Shore, S K; Bogart, S L; Reddy, E P (1990) Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation. Proc Natl Acad Sci U S A 87:6502-6

Shore, S K; Reddy, E P (1989) Transformation of NIH3T3 cells by A-MuLV proviral DNA: effect of plasmid linearization and carrier DNA on transformation efficiency. Oncogene 4:1411-3