Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048023-02
Application #
3191912
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1989-03-01
Project End
1994-02-28
Budget Start
1990-03-01
Budget End
1991-02-28
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Arch, R H; Thompson, C B (1999) Lymphocyte survival--the struggle against death. Annu Rev Cell Dev Biol 15:113-40
Pandey, A; Tjoelker, L W; Thompson, C B (1993) Restricted immunoglobulin junctional diversity in neonatal B cells results from developmental selection rather than homology-based V(D)J joining. J Exp Med 177:329-37
McCormack, W T; Hurley, E A; Thompson, C B (1993) Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens. Mol Cell Biol 13:821-30
Pickel, J M; McCormack, W T; Chen, C H et al. (1993) Differential regulation of V(D)J recombination during development of avian B and T cells. Int Immunol 5:919-27
Carlson, L M; Oettinger, M A; Schatz, D G et al. (1991) Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Cell 64:201-8
Carlson, L M; McCormack, W T; Postema, C E et al. (1990) Templated insertions in the rearranged chicken IgL V gene segment arise by intrachromosomal gene conversion. Genes Dev 4:536-47
Petryniak, B; Staudt, L M; Postema, C E et al. (1990) Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution. Proc Natl Acad Sci U S A 87:1099-103
McCormack, W T; Thompson, C B (1990) Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity. Genes Dev 4:548-58
Kim, S; Humphries, E H; Tjoelker, L et al. (1990) Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line. Mol Cell Biol 10:3224-31
McCormack, W T; Carlson, L M; Tjoelker, L W et al. (1989) Evolutionary comparison of the avian IgL locus: combinatorial diversity plays a role in the generation of the antibody repertoire in some avian species. Int Immunol 1:332-41