Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048049-08
Application #
2092873
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1989-01-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Polusani, Srikanth R; Kalmykov, Edward A; Chandrasekhar, Anjana et al. (2016) Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration. J Cell Sci 129:4399-4410
Chandrasekhar, Anjana; Kalmykov, Edward A; Polusani, Srikanth R et al. (2013) Intercellular redistribution of cAMP underlies selective suppression of cancer cell growth by connexin26. PLoS One 8:e82335
Xu, Ji; Nicholson, Bruce J (2013) The role of connexins in ear and skin physiology - functional insights from disease-associated mutations. Biochim Biophys Acta 1828:167-78
Mitra, Siddhartha S; Xu, Ji; Nicholson, Bruce J (2012) Coregulation of multiple signaling mechanisms in pp60v-Src-induced closure of Cx43 gap junction channels. J Membr Biol 245:495-506
Oshima, Atsunori; Tani, Kazutoshi; Toloue, Masoud M et al. (2011) Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. J Mol Biol 405:724-35
Ambrosi, Cinzia; Boassa, Daniela; Pranskevich, Jennifer et al. (2010) Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability. Biophys J 98:1809-19
Martínez, Agustín D; Acuña, Rodrigo; Figueroa, Vania et al. (2009) Gap-junction channels dysfunction in deafness and hearing loss. Antioxid Redox Signal 11:309-22
Beahm, Derek L; Oshima, Atsunori; Gaietta, Guido M et al. (2006) Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel. J Biol Chem 281:7994-8009
Sosinsky, Gina E; Nicholson, Bruce J (2005) Structural organization of gap junction channels. Biochim Biophys Acta 1711:99-125
Chandrasekhar, A; Merritt, M; Huh, S J et al. (2004) Connexin expression and cell coupling fail to reverse the v-src transformed growth characteristics of a Cx43-/- cell line. Cell Commun Adhes 11:103-19

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