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Ihle, Nathan T; Williams, Ryan; Chow, Sherry et al. (2004) Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther 3:763-72
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Meuillet, Emmanuelle J; Mahadevan, Daruka; Vankayalapati, Hariprasad et al. (2003) Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues. Mol Cancer Ther 2:389-99
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Husbeck, B; Berggren, M I; Powis, G (2001) DNA microarray reveals increased expression of thioredoxin peroxidase in thioredoxin-1 transfected cells and its functional consequences. Adv Exp Med Biol 500:157-68
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Powis, G; Montfort, W R (2001) Properties and biological activities of thioredoxins. Annu Rev Biophys Biomol Struct 30:421-55
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Kakolyris, S; Giatromanolaki, A; Koukourakis, M et al. (2001) Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer. Clin Cancer Res 7:3087-91
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Powis, G; Montfort, W R (2001) Properties and biological activities of thioredoxins. Annu Rev Pharmacol Toxicol 41:261-95
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Berggren, M M; Powis, G (2001) Alternative splicing is associated with decreased expression of the redox proto-oncogene thioredoxin-1 in human cancers. Arch Biochem Biophys 389:144-9
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Berggren, M I; Husbeck, B; Samulitis, B et al. (2001) Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin. Arch Biochem Biophys 392:103-9
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Baker, A; Santos, B D; Powis, G (2000) Redox control of caspase-3 activity by thioredoxin and other reduced proteins. Biochem Biophys Res Commun 268:78-81
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Freemerman, A J; Powis, G (2000) A redox-inactive thioredoxin reduces growth and enhances apoptosis in WEHI7.2 cells. Biochem Biophys Res Commun 274:136-41
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