Chemical and biological studies of several radioactive (67Ga, 99mTc, 99Tc, 111In) and non-radioactive (69,71Ga, 113,115In) isotopes of metal ions will be undertaken with functionalized 3-hydroxy-4-pyridinone and hydroxyacylfuran ligands. Because Ga, Tc, and In are all widely used in diagnostic nucelar medicine, the properties of the neutral, water- soluble complexes, both in vivo and in vitro, will be studied and used to design new radioagents. The ligands are chosen for the wide variety of substituents that can be attached, thereby providing some ability to alter their biodistributions as metal complexes. In-vivo biodistributions will be determined in mice. In-vitro properties of the complexes will be studied by octanol-water partitioning, stability-constant determination, and conventional spectroscopies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048964-03
Application #
3192876
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1989-09-01
Project End
1992-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of British Columbia
Department
Type
DUNS #
800772162
City
Vancouver
State
BC
Country
Canada
Zip Code
V6 1-Z3